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5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine) powder
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5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine) salt/powder:

5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine) is a powerful psychedelic tryptamine. It is found in a wide variety of plant and psychoactive toad species and, like its close relatives DMT and bufotenin, it has been used as an entheogen by South American shamans for thousands of years.

You can buy 5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine) powder online cheap (in low price) (in low price).

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Mechanism of Action
5-MEO-DMT acts on the serotonin system through the activation of serotonin receptors [R, R].

5-MEO-DMT exerts most of its effects by binding to 5-HT1A and 5-HT2A receptors. It also binds to 5-HT1B, 5-HT1C (weakly), 5-HT4, and 5-HT1S receptors (in the spinal cord) [R, R].

Its anti-inflammatory and neuro-regenerative effects are due to sigma-1 receptor (SIGMAR1) activation [R, R].

Finally, some of the effects may be due to the activation of 5-HT1B, 5-HT3, and GABAA receptors [R].

Activation of the 5-HT1A receptor releases serotonin, which is probably causing many of the effects seen after 5-MEO-DMT use, such as pain relief [R].

There are two types of neurons: presynaptic and postsynaptic. Presynaptic neurons send the signal and postsynaptic neurons receive the signal. Activating 5-HT1A receptors in the presynaptic neuron may increase pain, while activating the postsynaptic neuron may decrease pain [R].

5-MEO-DMT may produce anti-addiction effects to other drugs and substances by activating metabotropic glutamate receptor 5 (mGluR5) [R, R].

5-MEO-DMT is broken down by MAO-A. Combining 5-MEO-DMT with MAO-A inhibitors can prolong and increase its effect (plant preparations such as Ayahuasca and Syrian rue seeds contain MAO-A inhibitors, which increase their effectiveness) [R, R, R].

Use of MAO-A inhibitors with 5-MEO-DMT also increases levels of bufotenine, an active byproduct of 5-MEO-DMT. Harmaline increased levels of 5-MEO-DMT up to 3.6 fold and bufotenin by 9.9 fold in mice [R, R].

Health Effects of 5-MEO-DMT
1) 5-MEO-DMT May Protect the Brain and Improve Learning
Cell studies have shown that 5-MEO-DMT may decrease neuron death and brain lesions by inactivating genes that cause cells to die (e.g. Bcl-2). It accomplishes this by activating sigma-1 receptors (s1R) [R].

5-MEO-DMT may also regenerate neurons. 5-MEO-DMT increased numbers of dendrites in neurons, which are the parts that receive signals. Increasing dendrites can increase learning capabilities in humans by increasing their excitability (LTP) [R, R].

5-MEO-DMT may also contribute to brain plasticity. In this case, brain plasticity, as activated through the sigma-1 receptor, can also lead to sensations of novelty and awe [R].

These are commonly associated with psychedelic drugs.

However, the same study found that 5-MEO-DMT decreased levels of srGAP, a protein that has a role in cognitive function, learning, and memory [R].

2) 5-MEO-DMT May Decrease Inflammation
In cell studies, 5-MEO-DMT decreased the production of inflammatory molecules IL-1ß, IL-6, IL-8, and TNF-a. It increased the production of the anti-inflammatory molecule IL-10 [R].

The drug decreases nuclear factor kappa B (NF-?B). NF-?B inhibition decreases activation of inflammatory cytokines [R, R].

5-MEO-DMT also decreased the abilities of white blood cells to activate other immune cells such as Th1 and Th17 T-cells. These are overactive in autoimmune and chronic inflammatory diseases [R].

3) 5-MEO-DMT May Reduce Pain
In rats, high doses (1.6 – 25µg) of 5-MEO-DMT reduced pain by 13 to 24%, most likely due to increased activation of serotonin receptors (5-HT1A) [R, R].

In people with low noradrenaline, 5-MEO-DMT may not produce its pain-relieving effects. This is due to the fact that noradrenaline plays an important role in the serotonin pathway, which is what causes the pain relief [R, R].

5-MEO-DMT in low doses can also increase pain. Activation of serotonin receptors (e.g. 5-HT2B and/or 5-HT7) can lead to pain, as in migraines [R, R].

4) 5-MEO-DMT May Reduce Addiction
5-MEO-DMT works by decreasing the activation of the mGluR5 receptor, which produces rewarding effects in some addictive drugs. Mice without mGluR5 do not consume cocaine due to reduced addiction [R, R].

Ayahuasca has the potential ability to reduce addiction [R, R, R]. Some of its effects may actually be due to 5-MEO-DMT.

5) 5-MEO-DMT May Improve Response to Antidepressants
In cell studies, 5-MEO-DMT increased a class of receptors called integrins. Increased integrins are seen in patients who respond better to antidepressants [R].

Negative Effects of 5-MEO-DMT
1) 5-MEO-DMT Can Be Toxic and even Cause Death
One user combined 5-MEO-DMT with an MAO-A inhibitor (harmaline), which led to severe poisoning and death [R].

A separate account of a 25-year-old man who made an Ayahuasca preparation containing harmaline, 5-MEO-DMT, and DMT was found dead the morning after ingestion [R].

2) 5-MEO-DMT May Cause Body Temperature Fluctuations
In rats, 5-MEO-DMT lowered body temperature drastically (hypothermia) in low doses, while higher doses raised body temperature (hyperthermia) [R].

In mice, 5-MEO-DMT caused hypothermia by stimulating serotonin receptor 5-HT1A, while hyperthermia was caused by stimulating the 5-HT2A receptor [R].

3) 5-MEO-DMT May Cause Hyper- or Hypoactivity
In rats, 5-MEO-DMT with an MAO-A inhibitor decreased movement in the first 30 minutes and increased it in the next 30. 5-MEO-DMT alone only decreased movement [R].

Other animal studies show similar results. A rat and a mouse study saw that low doses of 5-MEO-DMT with an MAO-A inhibitor caused extreme hyperactivity in 45 minutes to three hours (due to 5-HT2A activation) [R, R].

However, another rat study only saw decreased activity after 5-MEO-DMT (due to 5-HT1A activation) [R].

4) 5-MEO-DMT May Cause Serotonin Syndrome
Due to 5-MEO-DMT’s ability to raise levels of serotonin and decrease its reuptake, it may lead to a condition called serotonin syndrome. Serotonin syndrome, which is a group of symptoms that can occur (e.g. fever, diarrhea, sweating) due to excessive serotonin-affecting drug use, can lead to death due to excessive serotonin-induced toxicity [R, R].

5) 5-MEO-DMT Can Cause Seizures
In one case study, a 5-year-old boy licked a Bufo alvarius toad leading to ingestion of 5-MEO-DMT. The boy was sent to the hospital with seizures and took a week to fully recover [R].

6) 5-MEO-DMT May Increase Pain
In rats, low doses of 5-MEO-DMT increased pain [R].

Safety
5-MEO-DMT is more potent than DMT, and may also cause stronger side effects.

Those with hyperserotonergic (high serotonin) disorders (e.g. autism spectrum



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5-MeO-DMT - (5-Methoxy-N - N-Dimethyltryptamine) Powder

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